Figure 2
Co-differentially-expressed genes in STZ treated T1D mice with cardiac dysfunction. (A) Heat map represents data of all 10 differentially expressed genes in STZ-treated diabetic mice compared with control. Genes were identified by performing t tests on the large original dataset and comparing each diabetic group with the relative control group. Features with significantly different expression (P < 0.05) were included. The heat map is organized with individual samples arranged along the Y-axis, and the relative ratios of expression are indicated by color. Color intensity is scaled as highest expression corresponding to bright red and the lowest expression corresponding to bright blue. Genes that are up- or down-regulated ≥ 2-fold are displayed in red (up-regulation) and blue (down-regulation) respectively. (B) qRT-PCR expression bar diagram of all 10 differentially expressed genes. (C) Correlation in gene expression between microarray (x-axis) and qRT-PCR (y-axis) changes in gene expression with r = 0.8171; *P < 0.05.
