Figure 5 | Scientific Reports

Figure 5

From: HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk

Figure 5The alternative text for this image may have been generated using AI.

Functional gene networks identified using IPA for STZ-induced T1D with cardiac dysfunction. (A) Representative diagram of top network identified named as Amino acid Metabolism, Small Molecule Biochemistry, Cellular Development (IPA score 17). Nodes represent genes, whereas shapes represent a functional class of gene product. Intensity of the node color indicates the degree of overexpression (red) and the degree of down-regulation (green). Genes in uncolored nodes were not identified as differentially expressed and were integrated into computationally generated networks based on information in the IPA database. The network diagram was generated by Ingenuity® Pathway Analysis software (QIAGEN, Bioinformatics, Redwood City, CA), www.qiagenbioinformatics.com. (B) Differential expression profile of MAPKs and NFkB in heart tissue of the control and STZ treated mice.

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