Figure 6
From: 0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop
The anti-cancer effects of 0404 was closely related to miR-34a. (A) 0404 increased miR-34a level in a concentration-dependent manner in HepG2 cells (p53 WT). (B) Expression of SIRT1 protein and acylation of p53 after 0404 treatment. (C) MiR-34a inhibitor attenuated the inhibitory effects of 0404 in HepG2 growth when compared with the NC inhibitor. (D) SIRT1 expression significantly elevated in 0404 + miR-34a inhibitor group.
