Figure 5 | Scientific Reports

Figure 5

From: Phthalide Derivatives from Angelica Sinensis Decrease Hemoglobin Oxygen Affinity: A New Allosteric-Modulating Mechanism and Potential Use as 2,3-BPG Functional Substitutes

Figure 5

Synergetic effects of phthalide derivatives and 2,3-BPG in modulating Hb allostery. The P50 values for Hb treated with (a) z-butylidenephthalide, (b) z-ligustilide, (c) senkyunolide A, and (d) senkyunolide I of 0.6 mM (green curves), 1.2 mM (orange curves) and 4.0 mM (purple curves) at varying 2,3-BPG levels. The P50 evolution for Hb treated with 2,3-BPG only (gray curves) is also shown as reference. (e) OEC for: pure Hb (gray curve), Hb treated with 1.2 mM 2,3-BPG (red curve), Hb treated with 1.2 mM 2,3-BPG and 1.2 mM z-butylidenephthalide (orange curve), and Hb treated with 1.2 mM 2,3-BPG and 4.0 mM z-butylidenephthalide (purple curve).

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