Figure 1 | Scientific Reports

Figure 1

From: IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model

Figure 1

Decreased IGF1R expression levels and changes in the lung transcriptome of prepubertal IGF1R-deficient mice. (a) Igf1r mRNA expression levels and (b) representative Western blots for IGF1R and graphical representation of densitometric measurements of band intensities (percentage) normalized to beta-Actin levels and quantified in eight-week-old UBC-CreERT2; Igf1r fl/fl (CreERT2) mice with respect to controls (Igf1r fl/fl). (c) Number of differentially expressed genes (percentage) found with significant changes (FDR < 0.1) in the lungs of UBC-CreERT2; Igf1r fl/fl (CreERT2) mice (n = 3), and (d) representation of the percentage of Igf1r-transcriptionally regulated genes involved in reported biological functions. Bars are color-coded in red and green for up- and down-regulated genes (respectively). Numbers within graphic bars indicate the number of mice analyzed and data are expressed as mean ± SEM. **p < 0.01 (Mann-Whitney U test). Up, up-regulated; Down, down-regulated.

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