Figure 3 | Scientific Reports

Figure 3

From: IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model

Figure 3

Reduced vascular fragility and lung permeability, and diminished leukocyte presence in BALF of IGF1R-deficient mice after BLM treatment. (a) Representative cytospin images, (b) quantification of number of erythrocytes per HPF, (c) total protein concentration and, (d) total and differential cell counts performed on cytospin preparations of BALF from saline- or BLM-treated UBC-CreERT2; Igf1r fl/fl (CreERT2) vs. Igf1r fl/fl mice at D3. Scale bar: 20 µm. Numbers within graphic bars indicate the number of mice analyzed and data are expressed as mean ± SEM. *p < 0.05; **p < 0.01 ***p < 0.001 (Dunn Sidak multiple comparison test). SAL, saline; BLM, bleomycin; BALF, bronchoalveolar lavage fluid; HPF, high-power field.

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