Figure 4 | Scientific Reports

Figure 4

From: IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model

Figure 4

Decreased inflammation and increased resolution marker levels in IGF1R-deficient lungs following BLM treatment. (a) Representative images of H&E stained inflamed lung sections (scale bar: 0.5 mm), (b) quantification of inflamed lung area to total lung surface, (c,e) lung tissue mRNA expression of pro-inflammatory (Tnf, Il1b and Il6) and injury resolution phase (Il13, Csf1 and Cd209a) markers, and (d,f) TNF and IL13 levels in lung homogenate from BLM-treated UBC-CreERT2; Igf1r fl/fl (CreERT2) mice at D3. Numbers within graphic bars indicate the number of mice analyzed and data are expressed as mean ± SEM. *p < 0.05; **p < 0.01 (Mann-Whitney U test). BLM, bleomycin.

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