Figure 1

Six mice per group were inoculated by the intratracheal route with 1 × 10⁶ cells of L27/01 cryptococcal cells. Fluconazole (15 or 150 mg/kg/day) and amphotericin B (0.5 mg/kg/day) alone or in combination were administered intraperitoneally (i.p.) from one day post-infection. Animals were monitored daily for the survival curve. All treatments significantly prolonged the median survival of mice infected. Treatment with 150 mg/kg/day fluconazole alone or in combination with amphotericin B and 15 mg/kg/day fluconazole in combination with amphotericin B improved the median survival of mice treated with antifungals in monotherapy. NI (not infected); NT (Control, untreated), AMB (Amphotericin B 0.5 mg/kg/day), FLC15 (Fluconazole 15 mg/kg/day), FLC150 (Fluconazole 150 mg/kg/day) FLC15 + AMB (Fluconazole 15 mg/kg/day + Amphotericin B 0.5 mg/kg/day), FLC150 + AMB (Fluconazole 150 mg/kg/day + Amphotericin B 0.5 mg/kg/day). ***P < 0.001 (compared with the NT group).