Figure 7
ANKRD22 regulated the cell cycle and cell proliferation by regulating E2F1. (A) Silencing of E2F1 reduced the promotion of cell growth by ANKRD22 in H1299 cells. (B) Silencing of E2F1 reduced the promotion of colony formation capacity by ANKRD22 in H1299 cells. (C) Silencing of E2F1 reduced promotion of the cell cycle by ANKRD22 in H1299 cells. (D) Silencing of E2F1 reduced promotion of the expression of E2F1 target genes CCNE2 and CDC6 by ANKRD22. Full-length blots are presented in Supplementary Figure S8. (n = 3, *P < 0.05).
