Table 1 Clinical features of 765 Italian NAFLD patients stratified by HCC diagnosis.

From: MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals

 

Hepatocellular carcinoma

p

Yes (n = 132)

No (n = 633)

Age, years

67.0 ± 8.8

47.5 ± 12.3

<0.001

Sex, Female

25 (19)

163 (26)

0.25

Obesity, yes

39 (32)

202 (32)

0.99

T2DM, yes

84 (64)

124 (20)

<0.001

Severe fibrosis, F3-4

111 (84)

99 (16)

<0.001

PNPLA3, I148M

  

<0.001

    I/I

31 (23)

231 (36)

 

    I/M

55 (42)

283 (45)

 

    M/M

46 (35)

120 (19)

 

TM6SF2, E167K

  

0.30

    E/E

109 (83)

538 (85)

 

    E/K

19 (14)

88 (14)

 

    K/K

4 (3)

7 (1)

 

MBOAT7, rs641738 C > T

  

0.003

    C/C

26 (20)

213 (34)

 

    C/T

69 (52)

285 (45)

 

    T/T

37 (28)

135 (21)

 
  1. (): % values; T2DM: type 2 diabetes mellitus. Comparisons were performed by logistic regression setting HCC as dependent variable, and the association of genetic variants was analyzed assuming additive models.
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