Table 1 Study characteristics.

From: Effects of Aortic Valve Replacement on Severe Aortic Stenosis and Preserved Systolic Function: Systematic Review and Network Meta-analysis

Study name, Year

Comparison pairs

Age (mean, SD)

Gender (Male)

Diabetes

CAD

HTN

SYM

AVR

Median follow-up (Year)

Cohort study design

Clavel 2012

LFLG (187), NFHG (187), MAS (187)

69, 13.3

339 (60%)

132 (24%)

288 (51%)

395 (70%)

397 (71%)

307 (55%)

4.2

Retrospective

Eleid 2013

LFLG (53), NFHG (1249), NFLG (352), LFHG (50)

78, 11.9

753 (44%)

722 (42%)

472 (28%)

1250 (73%)

1193 (70%)

1121 (66%)

2.3

Retrospective

Fan 2015

LFLG (19), NFHG (59), NFLG (30), LFHG (80)

55, 11.4

99 (53%)

8 (4.3%)

NA

36 (19%)

111 (59%)

188 (100%)

4.9

Mixed

Hermann 2011

LFLG (11), MAS (17)

71, 7.4

11 (39%)

6 (21%)

NA

24 (86%)

12 (43%)

11 (39%)

0.75

Prospective

Kamperidis 2014

LFLG (48), NFLG (86)

76, 10

67 (50%)

34 (25%)

83 (62%)

98 (73%)

48 (36%)

134 (100%)

1.8

Retrospective

Maes 2014

LFLG (115), NFLG (90)

78, 10.2

145 (42%)

77 (22%)

73 (21%)

270 (77%)

129 (37%)

92 (26%)

2.3

Prospective

Maor 2014

LFLG (136), NFLG (273)

78, 11

172 (42%)

132 (33%)

164 (40%)

245 (60%)

NA

94 (23%)

2.92

Mixed

Mehrotra 2013

LFLG (38), NFLG (75), MAS (70)

78, 9.4

86 (47%)

37 (20%)

63 (34%)

161 (88%)

21 (12%)

0 (0%)

3

Retrospective

Melis 2013

LFLG (42), NFHG (169), NFLG (98), LFHG (54)

76.8

177 (49%)

104 (29%)

136 (38%)

270 (74%)

NA

216 (59%)

2.1

Retrospective

Mohty 2013

LFLG (99), NFHG (386), NFLG (172), LFHG (111)

74, 8

445 (58%)

161 (21%)

353 (46%)

476 (62%)

684 (89%)

699 (91%)

4.6

Retrospective

O’Sullivan 2013

LFLG (85), LFHG (208)

83, 5.2

118 (40%)

82 (28%)

164 (56%)

247 (84%)

199 (68%)

293 (100%)

1

Retrospective

Romero 2014

LFLG (776), MAS (2958)

78, 12.3

1324 (31%)

1048 (25%)

1684 (40%)

2072 (49%)

NA

432 (10%)

2.3

Retrospective

Schewel 2015

LFLG (104), NFHG (289)

81, 6.8

149 (38%)

116 (30%)

218 (55%)

345 (88%)

352 (90%)

393 (100%)

1

Prospective

Tribouilloy 2015

LFLG (57), NFLG (85), MAS (420)

77, 4.1

306 (54%)

179 (32%)

176 (31%)

421 (75%)

74 (13%)

0 (0%)

3.25

Retrospective

Yamashita 2015

NFLG (61), MAS (151)

76, 9

93 (44%)

73 (34%)

76 (36%)

164 (77%)

79 (37%)

0 (0%)

1.3

Retrospective

  1. MAS: moderate aortic stenosis; LFLG: low-flow low-gradient; NFLG: normal-flow low-gradient; IFLG: indeterminate-flow low-gradient; LFHG: low-flow high-gradient; NFHG: normal-flow high-gradient; IFHG: indeterminate-flow high-gradient; CAD: coronary artery disease; HTN: hypertension; SYM: symptoms present; AVR: aortic valve replacement.
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