Figure 5
From: LINE-1 hypomethylation is not a common event in preneoplastic stages of gastric carcinogenesis
Overall survival analyses of patients with GC based on LINE-1 methylation. (A) Patients with GC with high and low LINE-1 methylation status defined by cut-off 60% based on LINE-1 methylation in T-GC sample (low LINE-1 methylation 21.5%). (B) Kaplan-Meier analyses based on UICC tumor stage with significant surivival difference among the groups. (D) Kaplan-Meier analyses based on high (n = 63) and low (n = 17) LINE-1 methylation status (cut-off methylation 60%) (p = 0.59). (D) Kaplan-Meier analyses based on high ≥ 65% (n = 45), middle > 55% and <65% (n = 25) and low ≤55% (n = 10) LINE-1 methylation status (p = 0.51). (E) Kaplan-Meier analyses of survival difference based on LINE-1 methylation status in intestinal/mixed type GC (p = 0.36) and in (F) diffuse type GC (p = 0.63). Statistical comparison between curves was performed with Log-rank (Mantel-Cox) test.
