Table 2 Summary of the studies related to LINE-1 methylation in gastric cancer patients.

First Author	Year	Tissue origin	Tissues	Micro-dissection	Gastric cancer	Paired samples	Healthy controls	Preneoplastic/-cancerous stages	H. pylori status	Methods	LINE-1 in GC	Survival analysis	Ref.
Kupcinskas et al.	2017	Europe (mix)	fresh-frozen	no	80	yes	19	37	yes	PyroSeq	↓ in GC	↔
Song et al.	2016	Korea	FFPE	yes	434	no	no	no	no	PyroSeq		↓	34
Kim et al.	2016	Korea	FFPE	yes	no	no	no	89	yes	COBRA	↓ in HGIEN		40
Kosumi et al.	2015	Japan	FFPE	yes	87	yes	17	20	yes	PyroSeq	↓ in GC		41
Yang et al.	2014	Korea	FFPE, fresh-frozen	yes	88/115	no	22	39	yes	PyroSeq	↓ in GC		42
Shigaki et al.	2013	Japan	FFPE	yes	203	yes	no	no	no	PyroSeq	↓ in GC	↓	12
Saito et al.	2012	Japan	fresh-frozen	no	101	yes	83	82	yes	qMSP	↓ in GC		43
Pavicic et al.	2012	Europe (Finland)	FFPE	yes	58	yes	no	no	no	COBRA MS-MLPA	↓ in GC		15
Bae et al.	2012	Korea	FFPE	yes	198/59	no	no	190	yes	PyroSeq	↓ in GC/ adenoma	↓	18
Balassiano et al.	2011	Europe (mix)	FFPE	no	98/20	yes	15	no	no	PyroSeq	↓ in GC		44
Lee et al.	2011	Korea	FFPE	yes	53	yes	no	79	yes	COBRA	↓ in GC/ HGIEN		20
Yoshida et al.	2011	Japan	fresh-frozen	no	52	no	34	76	yes	PyroSeq	↓ in GC		45
Park et al.	2009	Korea	FFPE	yes	59	no	no	143	yes	COBRA	↓ in GC		19

qMSP: quantitative MSP (real-time); NA: non-available; FFPE: formalin-fixed paraffin-embedded tissue; PyroSeq: pyrosequencing; GC: gastric cancer; HGIEN: high-grade intraepithelial neoplasia; Ref: references.

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