Table 2 Age adjusted hazard ratio of cause specific mortality from the Cause of Death Registry (all cause, circulatory and lung cancer) and incident cancer from the Norwegian Cancer Registry (breast cancer and ovarian cancer) if the first and second offspring sex was boy among fathers and mothers born 1925–54 with follow up of from age 50.
Hazard ratio (95% CI) | |||||||
|---|---|---|---|---|---|---|---|
At least one offspringa Sex of first offspring | At least two offspringb Sex of first and second offspring | ||||||
Girl (ref) | boy | p-value (trend) | girl-girl (ref) | boy-girl/girl-boy | boy-boy | p-value (trend) | |
Mothers | |||||||
All causes (n = 93,518) | 1.00 | 1.02 (1.01–1.03) | 0.007 | 1.00 | 1.01 (0.99–1.03) | 1.02 (1.00–1.05) | 0.066 |
Cardiovascular (n = 22,072) | 1.00 | 1.04 (1.01–1.07) | 0.008 | 1.00 | 1.00 (0.96–1.04) | 1.06 (1.01–1.10) | 0.011 |
Lung cancer and COPD (n = 11,503) | 1.00 | 1.01 (0.97–1.04) | 0.780 | 1.00 | 0.96 (0.91–1.01) | 0.99 (0.94–1.05) | 0.907 |
Breast cancer (n = 30,649) | 1.00 | 1.00 (0.98–1.03) | 0.991 | 1.00 | 1.00 (0.96–1.03) | 0.99 (0.95–1.03) | 0.626 |
Ovarian cancer (n = 6935) | 1.00 | 1.00 (0.95–1.06) | 0.925 | 1.00 | 1.04 (0.96–1.13) | 1.02 (0.93–1.11) | 0.783 |
Fathers | |||||||
All causes (n = 196,867) | 1.00 | 1.00 (0.99–1.01) | 0.917 | 1.00 | 0.99 (0.97–1.00) | 1.00 (0.99–1.02) | 0.819 |
Cardiovascular (n = 75,557) | 1.00 | 1.00 (0.99–1.02) | 0.624 | 1.00 | 0.99 (0.97–1.01) | 1.00 (0.98–1.03) | 0.738 |
Lung cancer and COPD (n = 21,994) | 1.00 | 1.00 (0.97–1.02) | 0.763 | 1.00 | 1.01 (0.98–1.05) | 1.01 (0.96–1.05) | 0.726 |
Testicular cancer (n = 1948) | 1.00 | 0.97 (0.89–1.06) | 0.487 | 1.00 | 1.06 (0.93–1.20) | 1.08 (0.94–1.24) | 0.285 |
Prostate cancer (n = 31,827) | 1.00 | 1.00 (0.97–1.02) | 0.920 | 1.00 | 1.00 (0.97–1.03) | 0.98 (0.95–1.02) | 0.340 |
