Figure 5

Store-operated calcium entry (SOCE) inhibitor 2-APB attenuates the TGF-β2 effect on Fgf23 transcript levels in UMR106 cells. Arithmetic means ± SEM (n = 4) of Fgf23 mRNA abundance (relative to Tbp mRNA) in UMR106 cells incubated without (white bars) or with TGF-β2 (black bars, 10 ng/ml) in the absence or presence of SOCE inhibitor 2-APB (25 μM) for 24 h. **p < 0.01 indicates significant difference from the absence of TGF-β2. ^### p < 0.001 indicates significant difference between cells treated with TGF-β2 alone (2^nd bar) and cells treated with TGF-β2 and 2-APB (4^th bar) (ANOVA).