Table 2 Multi-dimensional gene-gene interaction in discovery stage and validation stage.

From: Gene-gene and gene-environment interactions influence platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients

Study Component

Phenotype

Model

Training Bal. Acc.

Testing Bal. Acc.

Sign Test (p)

CV Consistency

Discovery

Overall toxicity

 

rs2231142-rs228589-rs2929970

0.666

0.473

4 (0.828)

2/10

 

rs2228528-rs462779-rs2929970-rs189037

0.740

0.487

4 (0.828)

3/10

 

rs3776332-rs2228528-rs462779-rs2977549-rs189037

0.816

0.493

5 (0.623)

5/10

 

rs3776332-rs799917-rs2228528-rs462779-rs2977549-rs189037

0.885

0.565

6 (0.377)

4/10

Hematologic toxicity

 

rs799917-rs28688207-rs2977530

0.688

0.538

6 (0.377)

6/10

 

rs2231142-rs3859104-rs228589-rs2977549

0.761

0.517

4 (0.828)

2/10

 

rs799917-rs2228528-rs462779-rs4658-rs189037

0.841

0.527

7 (0.172)

4/10

 

rs3776332-rs799917-rs2228528-rs228589-rs462779-rs4658

0.906

0.533

5 (0.623)

5/10

Gastrointestinal toxicity

 

rs462779-rs2929970-rs189037

0.716

0.542

6 (0.377)

5/10

 

rs3776332-rs2070804-rs462779-rs189037

0.796

0.554

9 (0.012)

5/10

 

rs3776332-rs799917-rs2228528-rs2977549-rs189037

0.877

0.612

10 (0.001)

9/10

 

rs3776332-rs799917-rs2228528-rs4658-rs2977549-rs189037

0.922

0.593

7 (0.172)

5/10

Sensitivity

 

rs2228528-rs28688207-rs2977530

0.719

0.547

8 (0.055)

4/10

 

rs3776332-rs2228528-rs4658-rs2977549

0.801

0.501

5 (0.623)

3/10

 

rs3776332-rs2228528-rs228589-rs462779-rs2977549

0.877

0.516

5 (0.623)

2/10

 

rs3776332-rs799917-rs2228528-rs228589-rs462779-rs4658

0.933

0.547

9 (0.011)

4/10

Validation

Gastrointestinal toxicity

 

rs3776332-rs2070804-rs462779-rs189037

0.749

0.434

2 (0.989)

10/10

 

rs3776332-rs799917-rs2228528-rs2977549-rs189037

0.706

0.504

6 (0.377)

10/10

Sensitivity

 

rs2228528-rs28688207-rs2977530

0.530

0.471

4 (0.828)

10/10

 

rs3776332-rs799917-rs2228528-rs228589-rs462779-rs4658

0.810

0.448

2 (0.989)

10/10

Back to article page