Figure 7
Inhibition of autophagy does not perturb PAQR-1-dependent survival but compromises UPRER activation during ER stress. (A) Survival curves of WT (black) and paqr-1(tm3262) mutant (red) animals subjected to lgg-1(RNAi) (dashed) under normal conditions. Lifespan values are given in Table S1. (B) Mean fluorescence intensity values of day 4 p hsp-4 GFP transgenic animals (WT (white) or paqr-1 mutant (grey) background) in the presence of EV or lgg-1(RNAi). (C) Survival curves of WT (black) and paqr-1(tm3262) mutant (red) animals subjected to lgg-1(RNAi) (dashed) and under ER stress (tunicamycin, 50 μg/ml). Lifespan values are given in Table S1. (D) Mean fluorescence intensity values of day 4 p hsp-4 GFP transgenic animals (WT (white) or paqr-1 mutant (grey) background) in the presence of EV or lgg-1(RNAi) and tunicamycin (50 μg/ml, 24 h). Values in histograms represent means ± SEM from experiments performed on at least three separate occasions. **P < 0.01; ***P < 0.001.
