Figure 1 | Scientific Reports

Figure 1

From: Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis

Figure 1

Loss of CTB staining at the NMJs in the tibialis anterior muscle of early symptomatic SOD1 G86R mice. (A) Representative pictures of ganglioside distribution along motor axons, after staining with cholera toxin subunit B (CTB, green) and with neurofilament-L, synaptophysin and bungarotoxin (red). Scale bar = 50 µm. (B) Quantification showing the proportion of NMJs with normal cholera toxin subunit B (CTB) staining along motor axons in presymptomatic and early symptomatic SOD1G86R mice (B). WT 75d n = 5, SOD1 75d n = 5, WT 95d n = 5, SOD1 95d n = 6; ***p < 0.001. Mean ± SEM.

Back to article page