Table 2 Human NEK1-Interacting Proteins related to DNA damage response.

From: NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin

Gene	Uniprot ID	Protein	Reference
Base excision repair
STAT1	P42224	Signal transducer and activator of transcription 1-alpha/beta	D
MRE11	P49959	Double-strand break repair protein MRE11	8
UBR1	H3BUC4	E3 ubiquitin-protein ligase UBR1	B
KI13A	Q9H1H9	Kinesin-like protein KIF13A	A
Nucleotide Excision Repair
CKAP4	Q07065	Cytoskeleton-associated protein 4	A
Fanconi Anemia
FANCA	O15360	Fanconi anemia group A protein	D
RPA1	O95602	DNA-directed RNA polymerase I subunit RPA1	C
Mismatch Repair
PM2P1	A4D2B8	Putative postmeiotic segregation increased 2-like protein 1	D
MSH6	P52701	DNA mismatch repair protein Msh6	B
Double Strand Break Repair
NUP153	F6QR24	Nuclear pore complex protein Nup153	A
DMD	P11532	Dystrophin	B
FLNA	P21333	Filamin-A	B
VHL	P40337	Von Hippel-Lindau protein	79
53BP1	Q12888	Tumor suppressor p53-binding protein1	8
CDC73	Q6P1J9	Parafibromin	A
HORM1	Q86X24	HORMA domain-containing protein1	D
NSE2	Q96MF7	E3 SUMO-protein ligase NSE2	C
BTBD2	Q9BX70	BTB/POZ domain-containing protein2	C
XRCC5	P13010	X-ray repair cross-complementing protein5	80
BAZ1A	Q9NRL2	Bromodomain adjacent to zinc finger domain protein1 A	B
ATRX	P46100	Transcriptional regulator ATRX	8
RIF1	Q5UIP0	Telomere-associated protein RIF1	A
TLK1	Q9UKI8	Serine/threonine-protein kinase tousled-like 1	57
PDS5B	Q9NTI5	Sister chromatid cohesion protein PDS5 homologB	81
DNA Repair
CRYZL1	A6NHJ8	Quinone oxidoreductase-like protein1	D
C21ORF2	O43822	Chromosome 21 open reading frame2	82
KAT7	O95251	Histone acetyltransferase KAT7	B
ODB2	P11182	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex	A
VDAC	P21796	Voltage-dependent anion-selective channel protein1	22
PRS7	P35998	26 S protease regulatory subunit7	A
SMBP2	P38935	DNA-binding protein SMUBP-2	B
KC1E	P49674	Casein kinase I isoform epsilon	B
PSB3	P49720	Proteasome subunit beta type-3	C
CPT1A	P50416	Carnitine O-palmitoyltransferase1, liver isoform	B
PPP2R5C	Q13362	Serine/threonine-protein phosphatase 2 A 56 kDa regulatory subunit gamma isoform	8
ATR	Q13535	ATR	8
ATRIP	Q8WXE1	ATRIP	1 6
CTNNAL1	Q9UBT7	alfa-catulin (alfa-catenin-like)	8

A- NEK1 IP-LC-MS/MS; B- NEK1 IP-LC-MS/MS + cisplatin; C- phosphoproteome in NEK1 IP-LC-MS/MS; D- phosphoproteome in NEK1 IP-LC-MS/MS + cisplatin.

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Table 2 Human NEK1-Interacting Proteins related to DNA damage response.

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