Figure 1 | Scientific Reports

Figure 1

From: Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats

Figure 1

Acute administration of GLP-1 (7–36) at more than 5 nmol/kg BW increases c-fos expression and BDNF content in the hypothalamus through hepatic afferent nerves. (a and b) Quantification of c-fos expression in the VMH (a) and BDNF content (b) in the hypothalamus of each group (n = 6). (c) Representative c-fos staining in the VMH of brain sections from each group. Red circle indicates the VMH area in the hypothalamus. *p < 0.05 vs. GLP-1 (7–36) (0 nmol/kg), Treatments: GLP-1; intraperitoneal administration of GLP-1 (7–36), Sham; sham operation, VgX; hepatic afferent vagotomy. 3 V; third ventricle. Scale bar = 100 μm.

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