Figure 2 | Scientific Reports

Figure 2

From: Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats

Figure 2

Chronic administration of GLP-1 (7–36) (5 nmol/kg BW) also increases c-fos expression and BDNF content in the hypothalamus through hepatic afferent nerves. (a) Representative c-fos staining of brain sections from each group. Red circle indicates the VMH area in the hypothalamus. (b and c) Quantification of c-fos expression in the VMH (b) and BDNF content in the hypothalamus (c) of each group (n = 6). *p < 0.05 vs. Standard (Sham, PBS) group, # p < 0.05 vs. HFD (Sham, PBS) group, $ p < 0.05 vs. HFD (Sham, GLP-1) group. Treatments: PBS; intraperitoneal administration of PBS, GLP-1; intraperitoneal administration of GLP-1 (7–36), Standard; fed with standard diet, HFD; fed with high-fat diet, Sham; sham operation, VgX; hepatic afferent vagotomy. 3 V; third ventricle. Scale bar = 100 μm.

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