Figure 3 | Scientific Reports

Figure 3

From: Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats

Figure 3

Chronic administration of GLP-1 (7–36) (5 nmol/kg BW) restores obesity-induced alterations in β-cell mass and proliferation in islets through hepatic afferent nerves. (a) Representative insulin staining (left row) and Ki-67 staining (right row) performed on pancreas sections from each group. (b and c) Insulin-positive area (b) and percentage of proliferating β-cells (c) in each group (n = 6). *p < 0.05 vs. Standard (Sham, PBS) group, # p < 0.05 vs. HFD (Sham, PBS) group, $ p < 0.05 vs. HFD (Sham, GLP-1) group. Treatments: Standard; fed with standard diet, HFD; fed with high-fat diet, Sham; sham operation, VgX; hepatic afferent vagotomy, PBS; intraperitoneal administration of PBS, GLP-1; intraperitoneal administration of GLP-1 (7–36). Scale bar = 100 μm.

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