Figure 4 | Scientific Reports

Figure 4

From: Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats

Figure 4

Chronic administration of GLP-1 (7–36) (5 nmol/kg BW) restores the obesity-induced enlargement of β-cell mass and improves glucose metabolism through pancreatic efferent nerves. (a and b) Representative insulin staining in islets (a) and insulin-positive area (b) in each group (n = 6). (c) Blood glucose (upper) and plasma insulin (lower) levels during the glucose tolerance tests in each group (n = 6). *p < 0.05 vs. Standard (Sham, PBS) group, # p < 0.05 vs. HFD (Sham, PBS) group, $ p < 0.05 vs. HFD (Sham, GLP-1) group. Treatments: PBS; intraperitoneal administration of PBS, GLP-1; intraperitoneal administration of GLP-1 (7–36), Standard; fed with standard diet, HFD; fed with high-fat diet, Sham; preservation of pancreatic efferent sympathetic nerve with PBS administration, SpX; pancreatic efferent sympathectomy with 6-OHDA administration. Scale bar = 100 μm.

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