Figure 6
From: Dopamine 2 Receptor Activation Entrains Circadian Clocks in Mouse Retinal Pigment Epithelium
DA treatment increases Per1 and Per2 mRNA in RPE-choroid. RPE-choroid cultures were prepared and treated with DA or vehicle at ZT6 (A, advance) or ZT 23 (B, delay) as indicated above, followed by collection for Q-PCR analysis of the indicated mRNAs at 1 or 3 hour intervals. Expression data were normalized using 18S, and are plotted relative to vehicle controls. Blue bars indicate mean ± SEM of vehicle control. Red bars indicate mean ± SEM of DA treated. *Indicates p < 0.05 (t-test) compared to vehicle controls (n = 3–6 in each group).
