Figure 2
The sorted loadings of the top hepatic sample eigenvectors and their interpretations. (A,B) The AUC (area under curve) results of GTT and ITT of mouse samples from week 18 were respectively sorted in the ascending order. Shown from top to bottom are the sub-groups of RC, HFD-W18-Gb, and HFD-W18-Gw accordingly. (C) The sorted loadings of the hepatic first sample eigenvector from the SVD of the HFD and RC samples. The samples from week 18 were at the bottom. Similar to the ITT (B) and GTT (A) sorting, the HFD-W18-Gb subgroup located on top of the HFD-W18-Gw subgroup, and even further, on top of the RC samples at week 18. (D) Derived from (C) by keeping only RC samples. (E) When SVD was carried out only for the RC hepatic samples, the sorted loading of its first sample eigenvector displayed a chronological order. The consistency between (D) and (E) indicates that the first eigen-component reflected an endogenous state of the liver. (F) the sorted loadings of the second sample eigenvector from the SVD of the combined samples. The clear-cut separation of the RC and HFD samples indicates that the second hepatic eigen-component reflected the driving impact from HFD.
