Figure 4
Summarization of the biological processes and molecular functions enriched at the two ends of the top gene eigenvectors. The up-enriched categories are shown on the right in red, whereas the down-enriched ones are shown on the left in green. (A) The hepatic first or endogenous gene eigenvector \({{\rm{u}}}_{1}\,\)coupled with v1 in Fig. 2C. (B) The hepatic HFD, or second gene eigenvector \({{\rm{u}}}_{2}\,\)coupled with v2 in Fig. 2F. (C) The adipose first gene eigenvector \({{\rm{u}}}_{1}\,\)coupled with v1 in Fig. 3A. (D) The pancreatic HFD, or first gene eigenvector \({{\rm{u}}}_{1}\,\)coupled with v1 in Fig. 3B. (E) The pancreatic development, or second gene eigenvector \({{\rm{u}}}_{2}\,\,\)couplded with v2 in Fig. 3C. Notably, the KEGG pathway of valine, leucine and isoleucine degradation were down-enriched at the HFD and mature end of the top adipose eigenvector (C) while up-enriched at both the mature end of the hepatic first/endogenous eigenvector (A) and the mature end of the pancreatic second/development eigenvector (E). The JASPAR motif PPARG::RXR was down-enriched (p-value = 0.0082) at the HFD and mature end of the top adipose eigenvector (C) while up-enriched (p-value = 0.013) at the mature end of the hepatic first/endogenous eigenvector (A).
