Figure 5
The loadings of the top gene eigenvectors on the KEGG insulin signaling pathway12. (A) The adipose first gene eigenvector. The down-regulated genes at the HFD and mature end are marked in blue and up-regulated ones are marked in red. The most down-regulated critical genes included Insr, Irs1, Glut4, and PGC-1. The top gene eigenvector captured the most distinguished pattern of insulin resistance in the adipose induced by HFD. (B) The hepatic HFD or second gene eigenvector. In contrast, the hepatic HFD eigenvector did not show an obvious down-regulation pattern.
