Figure 2 | Scientific Reports

Figure 2

From: Deoxyarbutin displays antitumour activity against melanoma in vitro and in vivo through a p38-mediated mitochondria associated apoptotic pathway

Figure 2

dA induced cell cycle arrest and motivated apoptosis in B16F10 cells. (a) Number of apoptosis cells and DNA cell cycle rate in B16F10 cells was analyzed by using flow cytometry after treating with 50 μM dA for 24 h. Vehicle indicated cells without treating dA. (b) The apoptotic rates and cycle arrest rate of B16F10 cells after dA treatment. (c) Morphologic changes in B16F10 cells were examined by using DAPI fluorescence staining. (d,e) TEM images showing the microcosmic changes after treatment 50 μM of dA in B16F10 cells (d) and NIH3T3 cells (e). Lower panel indicated the local mitochondrial microcosmic changes in both groups. Data are presented as mean ± s.d. of the three independent experiments. *p < 0.05, **p < 0.01 compared with the Vehicle group.

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