Figure 4
Gene Ontology, protein-protein interaction and disease association analysis of differentially expressed proteins upon rGal3C treatment. (A) Top five of biological process, cell component and molecular function of up-regulated proteins. (B) Top five of biological process, cell component and molecular function of down-regulated proteins. The −log10 p-value of the enrichment is shown on the x-axis, and the numbers represent the number of associated proteins associated with each term. (C) An interaction network of the proteins affected by rGal3C. The up-regulated proteins are represented by red nodes. The down-regulated proteins are represented by blue nodes and galectin-3 by yellow nodes. The red edge represents a strong close relationship between two nodes, and the blue edge represents an ordinary one. (D) Diseases associated with the differentially expressed proteins. The up-regulated proteins are represented by red nodes, and the down-regulated proteins are represented by blue nodes. Top ten of diseases associated with the differentially expressed proteins are represented by yellow ovals, and their P values are shown.
