Figure 7

Pyrithiamine significantly reduced TDBTN, TDBL and soma size. (A) Representative images of hippocampal neurons treated with saline or Pyrithiamine (PT, 50 μM) for 48 hours (DIV7 – DIV9). Scale bar: 20 μm. (B) Quantitation of TDBTN: saline (1.00 ± 0.04), PT (0.66 ± 0.03, P < 0.001). (C) Quantitation of TDBL: saline (1.00 ± 0.03), PT (0.67 ± 0.03, P < 0.001). (D) Quantitation of soma size: saline (1.00 ± 0.03), PT (0.81 ± 0.03, P < 0.001). (E) A significant correlation between TDBTN and soma size (n = 120, R² = 0.43, P < 0.001). (F) A significant correlation between TDBL and soma size (n = 120, R² = 0.25, P < 0. 001).