Figure 3 | Scientific Reports

Figure 3

From: Hyper-Stain Inspector: A Framework for Robust Registration and Localised Co-Expression Analysis of Multiple Whole-Slide Images of Serial Histology Sections

Figure 3

A demonstration of the registration algorithm’s refinement process. Figure 3a shows a visual field from the reference image, with a close-up of part of this region shown in Fig. 3b. Figure 3c shows the equivalent visual field from the registered image following approximate registration but before the registration refinement, and the equivalent close-up region is shown in Fig. 3d. Figure 3e shows the equivalent visual field from the registered image following registration refinement, and the equivalent close-up region is shown in Fig. 3f. It can be seen that the alignment of the two images is far better on a local level after refinement.

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