Table 3 Significant nervous system-related categories identified in the disease and functional enrichment analyses using IPA software, considering 40 genes identified in the gene-wide analyses surpassing follow-up significance threshold (P-value < 1e-03).
Super-Categories | Diseases or Functions Categories | P-value | Molecules |
|---|---|---|---|
Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities | autosomal dominant spastic paraplegia type 4 | 1.85e-03 | SPAST |
Developmental Disorder, Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities | autosomal recessive mental retardation type 39 | 1.85e-03 | TTI2 |
Developmental Disorder, Neurological Disease, Organismal Injury and Abnormalities | meroanencephaly | 1.85e-03 | ALX1 |
Organismal Development | relaxation of mice | 5.55e-03 | ATP1A1 |
Connective Tissue Disorders, Developmental Disorder, Neurological Disease, Skeletal and Muscular Disorders | acrania | 7.40e-03 | ALX1 |
Cell Morphology, Cellular Assembly and Organization, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Neurological Disease, Organismal Injury and Abnormalities | swelling of neurites | 7.40e-03 | SPAST |
Nervous System Development and Function | antinociception of spinal cord | 9.24e-03 | GPER1 |
Cellular Assembly and Organization, Cellular Function and Maintenance, Nervous System Development and Function | axonal transport of vesicles | 9.24e-03 | SPAST |
Nervous System Development and Function | abnormal morphology of nervous system | 1.10e-02 | ALX1, MAB21L2, PEA15, RAP1B, SPAST, STXBP3 |
Connective Tissue Disorders, Developmental Disorder, Organismal Development, Skeletal and Muscular Disorders | clefting of face | 1.29e-02 | ALX1 |
Embryonic Development, Nervous System Development and Function, Organismal Development, Tissue Morphology | abnormal morphology of neural crest | 1.47e-02 | NCSTN |
Cell Morphology, Nervous System Development and Function, Tissue Morphology | abnormal morphology of neurites | 3.92e-02 | RAP1B, SPAST |
Connective Tissue Development and Function, Organ Morphology, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development | abnormal morphology of supraoccipital bone | 4.00e-02 | ALX1 |
Behavior | addiction behaviour | 4.36e-02 | ATP1A1 |
Cell Morphology, Nervous System Development and Function, Neurological Disease, Tissue Morphology | loss of axons | 4.89e-02 | RAP1B |
