Table 1 Difference in the bacterial communities in the three types of laryngeal samples.

	Tumors^a	NATs^b	Controls^c	p1 ^d	Adjusted p1 ^e	p2 ^f	Adjusted p2 ^g	p3 ^h	Adjusted p3 ⁱ
	%	%	%	p1 ^d	Adjusted p1 ^e	p2 ^f	Adjusted p2 ^g	p3 ^h	Adjusted p3 ⁱ
Phyla
Firmicutes	35.9	36.9	63.6	0.898	0.898	0.001	0.002	0.003	0.012
Fusobacteria	25.4	18.4	7.6	0.246	0.328	0.001	0.002	0.021	0.042
Actinobacteria	1.5	0.7	4.7	0.132	0.328	0.085	0.085	0.034	0.045
Genera
Streptococcus	25.3	31.3	65.4	0.468	0.572	<0.001	0.006	<0.001	0.011
Fusobacterium	26.7	17.9	6.9	0.193	0.275	0.001	0.006	0.023	0.081
Gemella	6.3	4.2	1.8	0.230	0.275	0.008	0.018	0.064	0.117
Capnocytophaga	2.4	0.5	0.3	0.014	0.147	0.007	0.018	0.525	0.577
Parvimonas	1.8	0.9	0.2	0.186	0.275	0.003	0.011	0.104	0.163
Aggregatibacter	1.4	0.09	0.04	0.040	0.147	0.032	0.050	0.221	0.270
Peptostreptococcus	0.7	0.6	0.1	0.660	0.726	0.019	0.035	0.164	0.226
Helicobacter	0.1	8.6	0.4	0.098	0.289	0.390	0.423	0.110	0.179

^aThe tumors were tumor tissue samples from laryngeal cancer patients. ^bThe NATs refered to normal tissues adjacent to the tumor sites from laryngeal cancer patients. ^cThe controls were control tissue samples from vocal cord polyps subjects. ^dThe comparison of bacterial communities between the tumor tissues and the NATs was performed, and the p1 values were evaluated using Student’s t-test. ^eThe adjusted p1 values were adjusted by the false discovery rate (FDR). ^fThe differences in the bacterial communities between the tumor tissues and the control tissues were assessed, and the p2 values were evaluated using by Student’s t-test. ^gThe adjusted p2 values were adjusted by the FDR. ^hThe differences in the bacterial communities between the NATs and the control tissues were analyzed, and the p3 values were evaluated using Student’s t-test. ⁱThe adjusted p3 values were adjusted by the FDR.

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