Figure 4 | Scientific Reports

Figure 4

From: Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density

Figure 4

Action potential characterisation. (A) Example of action potentials (AP) and the AP upstroke velocity (inset) measured in human induced pluripotent stem cell-derived cardiomyocytes cultured in engineered heart tissue (EHT) or in human left ventricular tissue (LV) at 36.5 °C paced at 1 Hz. (B) Corresponding AP parameters. N: number of EHTs/LV tissues; n: number of impalements with the sharp microelectrode. RMP, resting membrane potential; APA, action potential amplitude; dV/dt, maximum upstroke velocity; APD90, AP duration at 90% repolarisation.

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