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Figure 1

From: Suppressed autophagic response underlies augmentation of renal ischemia/reperfusion injury by type 2 diabetes

Figure 1

Type 2 diabetes and chloroquine increased susceptibility of the kidney to ischemia/reperfusion injury. Serum creatinine (A) and blood urea nitrogen (BUN) (B) levels of LETO (N = 12), OLETF (N = 12), LETO treated with chloroquine (LETO+CQ, N = 8), and OLETF treated with chloroquine (OLETF+CQ, N = 10) at 24 h after ischemia and reperfusion. (C) Representative images of hematoxylin-eosin staining of renal tissues at 24 h after ischemia/reperfusion. (D) Tubular injury score of renal tissues of before ischemia (Pre) and 24 h after ischemia/reperfusion (I/R) in the four groups. *P < 0.05. Scale bar, 100 μm. NS = not significant.

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