Figure 3
Activation of renal autophagy after ischemia/reperfusion was reduced in OLETF. (A) Representative immunoblot images for p62 and LC3 in the kidney. Summary data for p62 (B) and LC3-II/LC3-I ratio, LC3-II, and LC3-I (C) in total kidney tissues before ischemia (Pre) and 24 h after ischemia/reperfusion (I/R). Ratio of LC3-II to LC3-I after I/R was significantly reduced in OLETF. Representative immunoblots for beclin-1 (D) and summary data (E) in kidney tissues. Beclin-1 protein level was increased after I/R only in LETO. N = 8 in each group. *P < 0.05, NS = not significant.
