Figure 6
Effects of rapamycin on kidney injury after ischemia/reperfusion in OLETF. Levels of serum creatinine (A) and blood urea nitrogen (BUN) (B) 24 h after renal ischemia/reperfusion in OLETF treated with a vehicle (N = 7) or rapamycin (Rapa, 0.25 mg/kg, N = 7) 30 min prior to ischemia in OLETF. (C) Representative images of hematoxylin-eosin staining of renal tissues at 24 h after ischemia/reperfusion. (D) Tubular injury score before ischemia and 24 h after reperfusion in OLETF treated with vehicle or rapamycin. Pre: pre-ischemia, I/R: 24 h after ischemia/reperfusion. *P < 0.05. Scale bar, 100 μm.
