Figure 7 | Scientific Reports

Figure 7

From: DGKδ triggers endoplasmic reticulum release of IFT88-containing vesicles destined for the assembly of primary cilia

Figure 7The alternative text for this image may have been generated using AI.

A model for IFT88 mediated secretory pathway from ER to primary cilia. IFT88 is found at the ER exit sites, where it is incorporated into the ER-derived COP II-coated vesicles. The IFT88 containing COP II vesicles travel directly to cilia bypassing the Golgi apparatus. The newly identified IFT88-binding protein DGKδ is colocalized with IFT88 at the ER exit sites and is required for triggering the release of IFT88 vesicles from the ER.

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