Figure 1 | Scientific Reports

Figure 1

From: Protein-protein binding selectivity and network topology constrain global and local properties of interface binding networks

Figure 1

PPINs all contain hub proteins and their IINs have distinctive topologies. We analyze the PPINs of the manually curated yeast endocytosis (a) and human ErbB networks (b) with all domains and interfaces identified and shown here colored by domain type (Table S2). The resulting interface interaction networks (IINs) in (c) and (d), respectively, have highly distinct topologies that reflect the needs of interfaces to achieve strong functional binding and minimize non-functional interactions. Both IINs break into multiple components with a selection of hub interfaces, and they contain an abundance of hub and square motifs with a minimal (or zero) number of triangle motifs.

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