Figure 3 | Scientific Reports

Figure 3

From: The resident pathobiont Staphylococcus xylosus in Nfkbiz-deficient skin accelerates spontaneous skin inflammation

Figure 3The alt text for this image may have been generated using AI.

Increased bacterial burden and decreased bacterial diversity in skin of Nfkbiz −/− mice. (A) Relative expression of 16 s rDNA universal bacteria in skin of Nfkbiz +/− and Nfkbiz −/− mice. (B) Principal coordinate analysis of unweighted and weighted UniFrac distances between samples from skin of Nfkbiz +/− and Nfkbiz −/− mice. (C) Shannon index, observed operational taxonomic units (OTUs), and phylogenetic diversity (PD) whole tree of Nfkbiz +/− and Nfkbiz −/− mice. (D) Composition of skin bacterial communities in Nfkbiz +/− and Nfkbiz −/− mice at phylum level (>1% of total 16S rRNA sequences) with additional speciation of Corynebacterium and Staphylococcus genera. Each bar represents relative abundance in one mouse. Results are representative of two experiments (n = 4–6 per group). (E and F) Quantification of Staphylococcus species from skin swabs of Nfkbiz +/− and Nfkbiz −/− mice performed using mannitol salt agar (MSA). Data are mean ± s.e.m. (A and F). *p < 0.05, **p < 0.01. n.d., not detected.

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