Table 1 Elimination of cancer stem cells via combined in vivo survivin knockdown and 5-FU treatment in vivo.
From: Aptamer-mediated survivin RNAi enables 5-fluorouracil to eliminate colorectal cancer stem cells
Treatment group | Number of cells/well | Estimated stem cell frequency | 95% confidence interval | ||||
|---|---|---|---|---|---|---|---|
50 | 20 | 10 | 5 | 1 | |||
Saline | 4/10 | 3/10 | 1/10 | 1/10 | 0/10 | 1.3% | 0.65–2.5% |
Saline + 5-FU | 5/10 | 1/10 | 1/10 | 0/10 | 0/10 | 0.99% | 0.47–2.1% |
Neg. chimera control + 5-FU | 3/9 | 1/7 | 1/10 | 0/10 | 0/10 | 0.76% | 0.32–1.8% |
Chimera | 3/7 | 1/10 | 1/10 | 0/10 | 0/10 | 0.81% | 0.30–1.9% |
Chimera + 5-FU | 1/10 | 1/10 | 0/10 | 0/10 | 0/10 | 0.24% | 0.06–0.97% |
