Table 2 Genotype and allele frequencies of MBL2 and KLRC4 polymorphisms in BD and healthy controls.
From: Genetic polymorphisms of C-type lectin receptors in Behcet’s disease in a Chinese Han population
Gene | SNP | Allele | BD | % | Controls | % | P Value | Pc Value | OR(95%CI) |
|---|---|---|---|---|---|---|---|---|---|
Genotype | N | N | |||||||
MBL2 | rs1800450 | ||||||||
stage1 | A | 188 | 24.2 | 284 | 19.1 | 5 × 10−3 | 0.26 | 1.351 (1.096–1.665) | |
G | 588 | 75.8 | 1200 | 80.9 | |||||
AA | 32 | 8.2 | 25 | 3.4 | 4.25 × 10−4 | 0.02 | 2.556 (1.492–4.308) | ||
AG | 124 | 32 | 234 | 31.5 | 0.885 | NS | 1.020 (0.783–1.327) | ||
GG | 232 | 59.8 | 483 | 65.1 | 0.079 | NS | 0.797 (0.619–1.027) | ||
stage2 | A | 198 | 26.2 | 332 | 17.8 | 1.31 × 10−6 | 6.70 × 10−5 | 1.637 (1.339–2.002) | |
G | 558 | 73.8 | 1532 | 82.2 | |||||
AA | 26 | 6.9 | 21 | 2.3 | 4.54 × 10−5 | 2.32 × 10−3 | 3.204 (1.780–5.769) | ||
AG | 146 | 38.6 | 290 | 31.1 | 0.009 | NS | 1.391 (1.084–1.785) | ||
GG | 206 | 54.5 | 621 | 66.6 | 3.72 × 10−5 | 1.90 × 10−3 | 0.6 (0.470–0.766) | ||
combined | A | 386 | 25.2 | 616 | 18.4 | 4.90 × 10−8 | 2.50 × 10−6 | 1.494 (1.293–1.726) | |
G | 1146 | 74.8 | 2732 | 81.6 | |||||
AA | 58 | 7.6 | 46 | 2.7 | 4.39 × 10−8 | 2.24 × 10−6 | 2.899 (1.949–4.312) | ||
AG | 270 | 35.2 | 524 | 31.3 | 5.40 × 10−2 | NS | 1.195 (0.997–1.431) | ||
GG | 438 | 57.2 | 1104 | 65.9 | 3.06 × 10−5 | 1.56 × 10−3 | 0.689 (0.579–0.821) | ||
KLRC4 | rs2617170 | ||||||||
stage1 | C | 342 | 44.1 | 807 | 54.4 | 3.25 × 10−6 | 1.66 × 10−4 | 0.661 (0.555–0.787) | |
T | 434 | 55.9 | 677 | 45.6 | |||||
CC | 79 | 20.4 | 228 | 30.7 | 2.00 × 10−4 | 1.02 × 10−2 | 0.576 (0.430–0.772) | ||
CT | 184 | 47.4 | 351 | 47.3 | 0.97 | NS | 1.005 (0.786–1.285) | ||
TT | 125 | 32.2 | 163 | 22 | 1.74 × 10−4 | 8.90 × 10−3 | 1.688 (1.283–2.222) | ||
stage2 | C | 333 | 44 | 1009 | 54.1 | 2.89 × 10−6 | 1.47 × 10−4 | 0.667 (0.563–0.791) | |
T | 423 | 56 | 855 | 45.9 | |||||
CC | 77 | 20.4 | 281 | 30.2 | 3.19 × 10−4 | 1.63 × 10−2 | 0.593 (0.445–0.789) | ||
CT | 179 | 47.4 | 447 | 48 | 0.84 | NS | 0.976 (0.768–1.240) | ||
TT | 122 | 32.3 | 204 | 21.9 | 8.16 × 10−5 | 4.16 × 10−3 | 1.701 (1.304–2.218) | ||
combined | C | 675 | 44.1 | 1816 | 54.2 | 4.03 × 10−11 | 2.05 × 10−9 | 0.664 (0.588–0.750) | |
T | 857 | 55.9 | 1532 | 45.8 | |||||
CC | 156 | 20.4 | 509 | 30.4 | 2.35 × 10−7 | 1.20 × 10−5 | 0.585 (0.477-0.718) | ||
CT | 363 | 47.4 | 798 | 47.7 | 0.897 | NS | 0.989 (0.833–1.173) | ||
TT | 247 | 32.2 | 367 | 21.9 | 4.96 × 10−8 | 2.53 × 10−6 | 1.695 (1.401–2.051) |
