Table 2 Function enrichment of up- and down-regulated PMI-associated genes in eight human tissues.

From: Systematic analysis of gene expression patterns associated with postmortem interval in human tissues

Tissues

Up-regulated gene set

Down-regulated gene set

ID

Description

FDR

ID

Description

FDR

Aorta Artery

GO:0042752

regulation of circadian rhythm

4.44E-02

GO:0006954

inflammatory response

3.31E-09

   

GO:0002250

adaptive immune response

1.29E-08

   

GO:0045087

innate immune response

2.27E-08

   

GO:0002224

toll-like receptor signaling pathway

6.25E-04

   

hsa04380

Osteoclast differentiation

2.20E-09

   

hsa05150

Staphylococcus aureus infection

7.81E-09

Tibial Artery

GO:0006413

translational initiation

6.00E-07

   

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

1.10E-05

   

GO:0006412

translation

1.84E-05

   

GO:0019083

viral transcription

4.41E-05

   

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

7.11E-05

   

GO:0003735

structural constituent of ribosome

8.86E-05

   

hsa03010

Ribosome

1.21E-04

   

Esophageal Mucosa

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

2.43E-09

GO:0002223

stimulatory C-type lectin receptor signaling pathway

1.16E-06

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

9.62E-09

GO:0002479

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

3.56E-06

GO:0019083

viral transcription

5.20E-08

GO:0006511

ubiquitin-dependent protein catabolic process

4.75E-06

GO:0006412

translation

1.72E-06

GO:0038061

NIK/NF-kappaB signaling

8.87E-06

GO:0006413

translational initiation

5.15E-05

hsa04141

Protein processing in endoplasmic reticulum

7.36E-07

GO:0003735

structural constituent of ribosome

1.03E-06

hsa04145

Phagosome

7.43E-06

hsa03010

Ribosome

2.38E-09

hsa03050

Proteasome

8.65E-04

Heart

hsa00190

Oxidative phosphorylation

7.93E-03

GO:0006457

protein folding

8.57E-04

hsa05012

Parkinson’s disease

1.95E-02

GO:0006954

inflammatory response

1.95E-03

hsa05010

Alzheimer’s disease

4.02E-05

GO:1904871

positive regulation of protein localization to Cajal body

2.56E-02

hsa05016

Huntington’s disease

1.93E-03

hsa05150

Staphylococcus aureus infection

9.61E-09

   

hsa04380

Osteoclast differentiation

1.80E-05

   

hsa04610

Complement and coagulation cascades

2.93E-03

Skeletal Muscle

GO:0006120

mitochondrial electron transport, NADH to ubiquinone

1.49E-25

GO:0043488

regulation of mRNA stability

1.87E-07

GO:0032981

mitochondrial respiratory chain complex I assembly

1.74E-22

GO:0038061

NIK/NF-kappaB signaling

1.68E-03

GO:0070125

mitochondrial translational elongation

8.12E-19

GO:0016032

viral process

2.56E-03

GO:0070126

mitochondrial translational termination

2.05E-16

GO:0036498

IRE1-mediated unfolded protein response

2.59E-03

hsa05012

Parkinson’s disease

2.88E-44

GO:0002223

stimulatory C-type lectin receptor signaling pathway

6.43E-03

hsa00190

Oxidative phosphorylation

1.18E-42

GO:0044822

poly(A) RNA binding

2.57E-16

hsa05016

Huntington’s disease

2.07E-34

hsa03050

Proteasome

7.14E-04

Tibial Nerve

GO:0007155

cell adhesion

3.42E-06

GO:0044822

poly(A) RNA binding

1.86E-02

GO:0007399

nervous system development

8.04E-04

   

GO:0030198

extracellular matrix organization

1.43E-03

   

GO:0030199

collagen fibril organization

1.17E-02

   

hsa04514

Cell adhesion molecules (CAMs)

3.30E-03

   

Thyroid

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

7.33E-10

   

GO:0006413

translational initiation

8.10E-10

   

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

3.80E-07

   

GO:0019083

viral transcription

4.07E-06

   

GO:0006412

translation

3.37E-05

   

GO:0003735

structural constituent of ribosome

7.78E-04

   

hsa03010

Ribosome

2.97E-06

   

Whole Blood

GO:0003714

transcription corepressor activity

4.41E-02

GO:0051301

cell division

3.85E-08

hsa04660

T cell receptor signaling pathway

5.11E-03

GO:0007067

mitotic nuclear division

1.01E-05

   

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

1.57E-05

   

GO:0051436

negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

3.02E-05

   

GO:0000082

G1/S transition of mitotic cell cycle

3.43E-05

   

GO:0000083

regulation of transcription involved in G1/S transition of mitotic cell cycle

4.91E-04

   

hsa04110

Cell cycle

2.64E-05

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