Figure 3
Top PatchDock predictions of epitope binding to MHC class I alleles as rendered by PyMOL Molecular Graphics System. Epitopes are shown as sticks with rainbow coloring (blue to red, N-terminus to C-terminus). HLA allele binding grooves are shown as cartoon with β-sheets in yellow, α-helices in red, and loops in green. DENV4 peptide KMSPGYVLGV did not bind within the binding groove of HLA-A*02:01 in any of the top ten PatchDock predictions. (a) ZIKV peptide KSYFVRAAK bound to HLA-A*03:01. (b) ZIKV peptide FLVEDHGFGV bound to HLA-A*02:01. (c) ZIKV peptide GVFHTSVWLK bound to HLA-A*03:01. (d) DENV1 peptide MLMTGTLAVF bound to HLA-A*02:01. (e) DENV2 peptide ILLVAVSFV bound to HLA-A*02:01. (f) DENV3 peptide MIAGVFFTFV bound to HLA-A*02:01. (g) DENV peptide MAIFIEEVMR bound to HLA-B*35:01. (h) DENV peptide MMLKLVTNF bound to HLA-B*15:01.
