Figure 6
Effect of β-PAE on the mRNA expression of c-fos and c-jun, miRNA expression of miR-21 and expression of NF-κB and ERK1/2 signalling-related proteins in the gastric mucosa of ethanol-induced rats (n = 3–5). Rats were intragastrically administered lansoprazole (30 mg/kg), PA (20 mg/kg) or β-PAE (10, 20 and 40 mg/kg) prior to intragastrical administration of ethanol. (A) The mRNA expression of c-fos (a) and c-jun (b), and the miRNA expression of miR-21 (c). (B) Expression of NF-κB signalling-related proteins (a and b) and ERK1/2 signalling-related proteins (c). Full-length blots/gels are presented in Suppl. Figure S6 and cropping lines are indicated in red color. The data are expressed as the mean ± SD and were analysed by ANOVA followed by LSD test. **P < 0.01, *P < 0.05 versus the vehicle group. Student’s t-test was performed to compare the drug and vehicle groups, ## P < 0.01.
