Figure 1
From: Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab
Crystal structures of PD-1 in complex with atezolizumab and durvalumab. (a) Ribbon representation of the complex structure of PD-L1/atezolizumab Fab fragment. (b) Ribbon representation of the complex structure of PD-L1/durvalumab Fab fragment. (c) Surface representation of the complex structure of PD-L1/atezolizumab Fab fragment. (d) Surface representation of the complex structure of PD-L1/durvalumab Fab fragment. PD-L1 and the antibody heavy and light chains are colored green, orange, and purple, respectively. In a–d, PD-L1 is in the same orientation. In c and d, the PD-1/PD-L1 complex (PDB code 4zqk) is superimposed onto the PD-L1 molecule in the PD-L1/anti-PD-L1 complexes with mixed ribbon/surface representation. PD-1 in the PD-1/PD-L1 complex are colored blue.
