Figure 4
From: Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab
Intrinsic structural rigidity of PD-L1. (a) Canonical designation of the strands (red labels) and loops (black labels) within PD-L1. The N- and C-termini are labeled in blue. (b) Superposition of the PD-L1 protein extracted from the structures in complex with PD-L1 (blue), atezolizumab (red), durvalumab (cyan), BMS-963559 (yellow), and avelumab (green). The arrow indicates the conformational change of the BC loop in PD-L1 upon binding to atezolizumab. The bound PD-1 protein is shown as a gray surface model. The orientation of PD-L1 is the same as that in (a).
