Figure 5 | Scientific Reports

Figure 5

From: CDK5-mediated phosphorylation of XBP1s contributes to its nuclear translocation and activation in MPP+-induced Parkinson’s disease model

Figure 5

Phosphorylated XBP1s acts as a transcription factor to induce the expression of multiple genes. (A) Unsupervised hierarchical clustering analysis of the differentially expressed genes between overexpressing vectors and XBP1s-S61D plasmid cell groups (based on fold change ≥2, P < 0.01). The rows represent different genes, and the columns represent overexpressing vectors and XBP1s-S61D samples. The color scale on the top shows the relative expression level of mRNAs: green represents upregulation and red represents downregulation. (B) The ratio of protein-coding RNAs and ncRNAs in differentially expressed genes (fold change ≥2, P < 0.01) is presented, and the proportion of different ncRNAs is shown in the smaller pie chart. (C) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the differentially expressed genes. The x-axis indicates the counts of genes and the y-axis indicates the terms.

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