Table 3 Odds ratios of difficulty going up/down stairs by statin use and 25-hydroxyvitamin D status, adjusted for inflammatory markers, BMI, knee OA, education, SEC and smoking (n = 1556).
Model A (Sex adjusted only) | Model B (Mutually adjusted with interaction) | Difficulty going up stairs | Model D = Model C + BMI & Knee OA | Model E = Model D + SEC, education & smoking† | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Model C = Model B + inflammatory markers | |||||||||||||||
OR | 95% CI | p value | OR | 95% CI | p value | OR | 95% CI | p value | OR | 95% CI | p value | OR | 95% CI | p value | |
Statin Use | 2.6 | (1.9,3.5) | <0.001 | ||||||||||||
25-hydroxyvitamin D | |||||||||||||||
Overall effect | 0.003 | ||||||||||||||
Normal >20 ng/l | 1.0 | ||||||||||||||
Insufficient 13–20 ng/l | 1.0 | (0.7,1.5) | |||||||||||||
Deficient <13 ng/l | 1.6 | (1.2,2.3) | |||||||||||||
Statin Use (vs non use) by 25-hydroxyvitamin D (Interaction) | |||||||||||||||
Statin Use in those with Normal >20 ng/l | 1.4 | (0.7,2.6) | 0.292 | 1.3 | (0.7,2.5) | 0.378 | 1.2 | (0.6,2.3) | 0.586 | 1.1 | (0.5,2.2) | 0.749 | |||
Statin Use in Insufficient 13–20 ng/l | 3.6 | (2.1,6.1) | <0.001 | 3.4 | (1.9,5.9) | <0.001 | 2.4 | (1.3,4.2) | 0.003 | 2.1 | (1.2,3.8) | 0.012 | |||
Statin Use in Deficient <13 ng/l | 2.7 | (1.7,4.3) | <0.001 | 2.8 | (1.7,4.5) | <0.001 | 2.2 | (1.3,3.6) | 0.003 | 2.1 | (1.2,3.5) | 0.005 | |||
IL6 (log pg/ml) | 1.4 | (1.1,1.7) | 0.007 | 1.3 | (1.0,1.7) | 0.022 | 1.3 | (1.0,1.6) | 0.049 | ||||||
CRP (log mg/l) | 1.6 | (1.3,1.9) | <0.001 | 1.4 | (1.1,1.7) | 0.001 | 1.3 | (1.1,1.6) | 0.006 | ||||||
BMI at 53 (per 1 kg/m2 increase) | 1.1 | (1.1,1.1) | <0.001 | 1.1 | (1.1,1.1) | <0.001 | |||||||||
Knee OA at 53 (Yes vs No) | 3.6 | (2.4,5.3) | <0.001 | 3.5 | (2.3,5.3) | <0.001 | |||||||||
Sex (Men vs Women) | 2.1 | (1.6,2.9) | <0.001 | 2.2 | (1.6,2.9) | <0.001 | 1.9 | (1.4,2.6) | <0.001 | 1.8 | (1.3,2.5) | <0.001 | |||
