Table 4 Difference in mean chair rise speed (stands/minute) by statin use and 25-hydroxyvitamin D status, adjusted for inflammatory markers, BMI, knee OA, education, SEC and smoking (n = 1556).

From: Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort

 

Model A (Sex adjusted only)

Model B (Mutually adjusted with interaction)

Chair Rise Speed/min

Model D = Model C + BMI & Knee OA

Model E = Model D + SEC, education & smoking†

Model C = Model B + inflammatory markers

Regression coefficient

95% CI

p value

Regression coefficient

95% CI

p value

Regression coefficient

95% CI

p value

Regression coefficient

95% CI

p value

Regression coefficient

95% CI

p value

Statin Use

−1.7

(−2.7, −0.7)

<0.001

            

25-hydroxyvitamin D

Overall effect

  

0.025

            

Normal > 20 ng/l

0

              

Insufficient 13–20 ng/l

−0.6

(−1.6, 0.3)

             

Deficient <13 ng/l

−1.3

(−2.3, −0.4)

             

Statin Use (vs non use) by 25-hydroxyvitamin D (Interaction)

Statin Use in those with Normal > 20 ng/l

   

−0.5

(−2.3, 1.4)

0.605

−0.4

(−2.2, 1.5)

0.702

0.0

(−1.8, 1.8)

0.968

0.1

(−1.7, 1.8)

0.952

Statin Use in Insufficient 13–20 ng/l

   

−2.3

(−4.0, −0.7)

0.006

−2.0

(−3.7, −0.4)

0.017

−1.3

(−2.9, 0.4)

0.128

−1.0

(−2.6, 0.7)

0.245

Statin Use in Deficient <13 ng/l

   

−1.8

(−3.4, −0.2)

0.023

−1.7

(−3.2, −0.1)

0.033

−1.0

(−2.5, 0.5)

0.207

−0.8

(−2.3, 0.7)

0.302

IL6 (log pg/ml)

      

−0.9

(−1.6, −0.3)

0.004

−0.8

(−1.4, −0.2)

0.014

−0.7

(−1.3, −0.1)

0.027

CRP (log mg/l)

      

−1.0

(−1.5, −0.5)

<0.001

−0.7

(−1.2, −0.1)

0.013

−0.5

(−1.0, 0.0)

0.058

BMI at 53 (per 1 kg/m2 increase)

         

−0.2

(−0.3, −0.1)

<0.001

−0.2

(−0.3, −0.1)

<0.001

Knee OA at 53 (Yes vs No)

         

−2.4

(−3.8, −1.1)

<0.001

−2.2

(−3.6, −0.9)

0.001

Sex (Men vs Women)

   

−1.0

(−1.8, −0.2)

0.010

−1.0

(−1.7, −0.2)

0.012

−0.9

(−1.6, −0.1)

0.026

−0.5

(−1.3, 0.2)

0.179

  1. †SEC, education & smoking not shown.
  2. *p-value = 0.32 for the interaction between statin use and 25-hydroxyvitamin D in Model B (formally tested using a likelihood ratio test comparing models with and without an interaction between 25-hydroxyvitamin D and statin use).
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